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　　12YUE10RI，ZHONGKEYUANGUANGZHOUSHENGWUYIYAOYUJIANKANGYANJIUYUANWANGJINYONGKETIZUHEZHONGGUOYIXUEKEXUEYUANXUEYEXUEYANJIUSUOSHIYANXUEYEXUEGUOJIAZHONGDIANSHIYANSHICHENGHUI/CHENGTAOKETIZUHEZUOGONGGUAN，ZAIZAOXUEGANXIBAOWENTAIDIAOKONGLINGYUYANJIUQUDEXINTUPO，ZUIJINZAIHaematologica（XUEYEXUEZAZHI）ZAIXIANFABIAOLETIWEILoss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathwayDELUNWEN。GAIYANJIUFAXIAN：ZHUANLUYINZINupr1TONGGUOp53XINHAOTONGLUDIAOKONGZAOXUEGANXIBAO（HSC）XIUMIANTAIHEJIHUOTAIDEZHUANHUAN，QIAOCHUNupr1DEHSCGENGDUODECHUYUZENGZHIQIBINGJUBEIGENGQIANGDEYIZHIJINGZHENGYOUSHI，ZHEIYIFAXIANJIESHILEHSCWENTAIDIAOKONGDEXINJIZHI。 

　　ZAOXUEGANXIBAO（HSC）JUYOUZIWOGENGXINNENGLIBINGNENGFENHUAWEIGEZHONGXUEYEXIBAO。SHENGLIZHUANGTAIXIA，ZAOXUEGANXIBAODABUFENCHUYUXIUMIANZHUANGTAI，JINYOUSHAOLIANGXIBAOZENGZHIYIWEICHIZAOXUEWENTAI。ERZAIYIXIEYINGJIZHUANGTAIXIA（RUSHIXUEGUODUO、FUSHESUNSHANG、HUALIAODENG），HSCNENGGOUXUNSUCONGXIUMIANTAIZHONGJIHUOJINXINGZAOXUE，DANGJITIZAICIHUIFUZHENGCHANGWENTAIHOU，HSCHUIZHONGXINJINRUXIUMIANZHUANGTAI。ZHEIZHONGJINGMIDEWENTAIWEICHISHISHOUDAOFUZADEJIZHIDIAOKONGDE，MUQIANWEIZHI，HSCXIUMIANTAIYUJIHUOTAIDEPINGHENGDIAOKONGJIZHISHANGBUMINGQUE。 

　　KETIZUQIANQIYANJIUFAXIAN，Nupr1JIYINZAIHSCZHONGDEBIAODASHUIPINGXIANZHUGAOYUZAOXUEDUONENGZUXIBAO（MPP）。WEILEYANJIUNupr1ZAIHSCZHONGDEZUOYONG，KETIZUGOUJIANLENupr1TIAOJIANXINGQIAOCHUXIAOSHUMOXING。JIEGUOFAXIAN，SHENGLIWENTAIXIANupr1QUESHIDEHSCGENGDUODEJINRUXIBAOZHOUQI，JINGZHENGYIZHISHIYANBIAOMINGNupr1-/- HSCZAITINEIJUBEIYIZHIJINGZHENGYOUSHI，TIWAIKUOZENGSHIYANYEXIANSHINupr1-/- HSCJUBEIGENGQIANGDEZENGZHINENGLI。JINYIBUZHUANLUZUCEXUJIEGUOJIESHI，Nupr1-/- HSCDEp53XINHAOTONGLUXIANZHUXIADIAO，SUIHOUJIANGNupr1-/- HSCZHONGDEp53BIAODASHUIPINGHUIDIAO，QIJINGZHENGYOUSHIXIAJIANG，SHUOMINGNupr1DUIHSCWENTAIDEDIAOJIESHITONGGUOp53XINHAOTONGLULAISHIXIANDE。GAIYANJIUDUIYUXUNQIUSHOUDUANGANYUHSCSHIXIANKUOZENG、GANXINGWEICHI、CUJINZHIRUDENGJUYOUZHONGYAOLILUNZHIDAOYIYI。 

　　WANGTONGJIE、XIACHENGXIANGWEIBENWENDEGONGTONGDIYIZUOZHE，WANGJINYONGHECHENGHUIWEIGAILUNWENDEGONGTONGTONGXUNZUOZHE。BENYANJIUDEDAOLAIZIGUOJIAZIRANKEXUEJIJIN、GUANGZHOUZAISHENGYIXUEYUJIANKANGGUANGDONGSHENGSHIYANSHIZHONGDIANYANFAXIANGMU、ZHONGGUOKEXUEYUANZHANLVEXINGXIANDAOKEJIZHUANXIANG、ZHONGGUOKEXUEYUANQIANYANKEXUEZHONGDIANYANJIUJIHUADENGXIANGMUDEJINGFEIZHICHI。 

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