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科研进展

亚博买球揭示造血干细胞稳态调控的新机制

发表日期:2020-12-17来源:放大 缩小

  12YUE10RI,ZHONGKEYUANGUANGZHOUSHENGWUYIYAOYUJIANKANGYANJIUYUANWANGJINYONGKETIZUHEZHONGGUOYIXUEKEXUEYUANXUEYEXUEYANJIUSUOSHIYANXUEYEXUEGUOJIAZHONGDIANSHIYANSHICHENGHUI/CHENGTAOKETIZUHEZUOGONGGUAN,ZAIZAOXUEGANXIBAOWENTAIDIAOKONGLINGYUYANJIUQUDEXINTUPO,ZUIJINZAIHaematologica(XUEYEXUEZAZHI)ZAIXIANFABIAOLETIWEILoss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathwayDELUNWEN。GAIYANJIUFAXIAN:ZHUANLUYINZINupr1TONGGUOp53XINHAOTONGLUDIAOKONGZAOXUEGANXIBAO(HSC)XIUMIANTAIHEJIHUOTAIDEZHUANHUAN,QIAOCHUNupr1DEHSCGENGDUODECHUYUZENGZHIQIBINGJUBEIGENGQIANGDEYIZHIJINGZHENGYOUSHI,ZHEIYIFAXIANJIESHILEHSCWENTAIDIAOKONGDEXINJIZHI。 

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  KETIZUQIANQIYANJIUFAXIAN,Nupr1JIYINZAIHSCZHONGDEBIAODASHUIPINGXIANZHUGAOYUZAOXUEDUONENGZUXIBAO(MPP)。WEILEYANJIUNupr1ZAIHSCZHONGDEZUOYONG,KETIZUGOUJIANLENupr1TIAOJIANXINGQIAOCHUXIAOSHUMOXING。JIEGUOFAXIAN,SHENGLIWENTAIXIANupr1QUESHIDEHSCGENGDUODEJINRUXIBAOZHOUQI,JINGZHENGYIZHISHIYANBIAOMINGNupr1-/- HSCZAITINEIJUBEIYIZHIJINGZHENGYOUSHI,TIWAIKUOZENGSHIYANYEXIANSHINupr1-/- HSCJUBEIGENGQIANGDEZENGZHINENGLI。JINYIBUZHUANLUZUCEXUJIEGUOJIESHI,Nupr1-/- HSCDEp53XINHAOTONGLUXIANZHUXIADIAO,SUIHOUJIANGNupr1-/- HSCZHONGDEp53BIAODASHUIPINGHUIDIAO,QIJINGZHENGYOUSHIXIAJIANG,SHUOMINGNupr1DUIHSCWENTAIDEDIAOJIESHITONGGUOp53XINHAOTONGLULAISHIXIANDE。GAIYANJIUDUIYUXUNQIUSHOUDUANGANYUHSCSHIXIANKUOZENG、GANXINGWEICHI、CUJINZHIRUDENGJUYOUZHONGYAOLILUNZHIDAOYIYI。 

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附件:
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